CZC-54252 hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

CZC-54252 Hydrochloride 是 LRRK2 的选择性抑制剂，对野生型和 G2019S LRRK2 的 IC50 分别为 1.85 nM 和 1.28 nM。

CZC-54252 hydrochloride is a selective inhibitor of LRRK2 with IC50s of 1.85 nM and 1.28 nM for wild-type and G2019S LRRK2. CZC-54252 hydrochloride has a neuroprotective activity and attenuates G2019S LRRK2-induced human neuronal injury with an EC50 of 1 nM.(In Vitro):CZC-54252 hydrochloride(1.6 nM) fully reverses G2019S LRRK2-induced human neuronal injury to wild-type levels. CZC-54252 hydrochloride inhibits the recombinant human wild-type LRRK2 with an IC50 ranging from 1 to 5 nM. CZC-54252 hydrochloride inhibits the G2019S mutant with an IC50 ranging from 2 to 7 nM in a TF-FRET assay.

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Autophagy

LRRK2

PBP2|β-Lactamase

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1784253-05-9

541.45

C22H26Cl2N6O4S

>98% (HPLC)

In Vitro:?DMSO : 33.33 mg/mL (61.56 mM)

Cl.O=S(=O)(NC=1C=CC=CC1NC2=NC(=NC=C2Cl)NC3=CC=C(C=C3OC)N4CCOCC4)C

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(-20℃)

With Ice Pack

≥ 2 years